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The efficacy and function of Sijunzi Decoction
2026-03-10 04:40:26
Sijunzi Decoction: a classic prescription for replenishing qi and strengthening the spleen.
Sijunzi Decoction is a basic prescription of traditional Chinese medicine to replenish qi and strengthen the spleen. It is composed of four medicinal herbs: ginseng (or dangshen), atractylodes, poria, and licorice. It mainly targets symptoms such as loss of appetite, fatigue, and loose stools caused by spleen and stomach qi deficiency. Its core functions areReplenishing qi and strengthening the spleen, secondary effects include enhancing immunity, improving digestive function, etc. The following will start with the analysis of the prescription, applicable groups, modern applications and precautions, and systematically introduce the value of this famous prescription through the ages.
Prescription analysis: synergistic effect of four medicinal materials

The compatibility of Sijunzi Decoction embodies the prescription principle of "monarch, minister, and envoy" of traditional Chinese medicine:Ginseng (Codonopsis pilosula) is the king medicine, greatly replenishing vitality;Atractylodes is a ministerial medicine, invigorating the spleen and drying dampness;Poria cocos as adjuvant, penetrate dampness and diuresis;Licorice as the medicine, to reconcile various medicines. The four medicines are combined to nourish but not stagnate, warm but not dry, and are especially suitable for people with weak spleen and stomach, shortness of breath and laziness. Modern research shows that this prescription can improve gastrointestinal function by regulating intestinal flora and promoting the secretion of digestive enzymes (see Table 1).
| Medicinal materials | Main ingredients | Modern pharmacological effects |
|---|---|---|
| Ginseng | Ginsenosides | Enhance immunity and fight fatigue |
| Atractylodes | Atractylodes ketone | Promote gastrointestinal motility |
| Poria | Poria polysaccharide | Regulate water and salt metabolism |
| Licorice | Glycyrrhizic acid | Anti-inflammatory, liver-protective |
Applicable groups and typical symptoms
Sijunzi Decoction is commonly used for three types of people: First,People with spleen and stomach qi deficiency, manifested by poor appetite and abdominal distension after meals; the second isThe chronically ill and infirm, such as postoperative or chronic disease patients; third,Sub-healthy people, such as those who are prone to fatigue and have low immunity. It should be noted that it should not be used by people with Yin deficiency and internal heat (such as dry mouth and tongue) or excessive heat syndrome (such as constipation, red tongue and yellow coating). Clinical cases show that this formula is effective in treating indigestion in children up to 85% (data source: "Journal of Traditional Chinese Medicine and Pediatrics").
Modern applications and extended prescriptions
As a basic prescription, Sijunzi Decoction is often combined with other medicinal materials to derive new recipes: such as adding tangerine peel and pinellia ternata.Liujunzi Soup(Cure phlegm and dampness), add woody scent and Amomum villosum.Xiangsha Liujunzi Soup(Treat qi stagnation). Modern research has also found that adjuvant chemotherapy with this prescription can reduce gastrointestinal reactions in patients ("Chinese Journal of Experimental Prescriptions"). It is recommended to consult a traditional Chinese medicine practitioner when using it, and adjust the dosage according to your physical condition to avoid dependence caused by long-term use alone.
Summary: The scientific value of classic prescriptions
Sijunzi Decoction uses simplicity to control complexity, and fundamentally improves physical fitness by nourishing qi and strengthening the spleen. Its formulation ideas are still a model for teaching traditional Chinese medicine. Both traditional application and modern research have verified its concept of "strengthening the foundation". It should be emphasized that TCM emphasizes syndrome differentiation and treatment, and patients should use it under professional guidance to avoid blind application.
Quote sources:
1. "Prescription Science" (People's Medical Publishing House, Editor-in-Chief: Deng Zhongjia)
2. "Research on the Modulation of Intestinal Microbiota by Sijunzi Decoction" published in the "Chinese Journal of Experimental Prescriptions" in 2021
3. "Taiping Huimin Hejiju Prescription" of the Ming Dynasty (the earliest official source of Sijunzi Decoction)
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