Structured content output: comprehensive analysis of Sishen Pills

First paragraph: Summary of content
Sishen Pill is a classic prescription of traditional Chinese medicine. It is composed of four medicinal materials: psoralen, nutmeg, Evodia and Schisandra chinensis. It is mainly used for treatment.Spleen and kidney yang deficiencyCaused by symptoms such as diarrhea at midnight and persistent diarrhea. This article will start from the four dimensions of its composition principle, efficacy characteristics, applicable groups and modern research, focusing on analyzing its core function of "warming and tonifying the spleen and kidneys, astringing the intestines and stopping diarrhea", supplemented by instructions on incompatibility and precautions, forming a hierarchical knowledge structure.

Paragraph 2: Principles and compatibility of prescriptions
The compatibility of Sishen Pills embodies the traditional Chinese medicine idea of "monarch, minister, assistant and envoy": psoralen is the monarch medicine, warming and tonifying kidney yang; nutmeg is the ministerial medicine, strengthening the spleen and warming the middle; Evodia rutae helps dispel cold and relieve pain; Schisandra chinensis is the medicine to astringe and fix astringency. The four medicines work together to form a triple mechanism of "warming-tonifying-astringent", which works simultaneously on the cause (insufficient yang qi) and symptoms (slippage) of spleen and kidney yang deficiency type diarrhea. The "Principles of Syndrome and Treatment" of the Ming Dynasty records that it "treats kidney diarrhea like a god", and the modern "Pharmacopoeia of the People's Republic of China" also includes this prescription.

Paragraph 3: Clinical Application and Verification
Clinical data shows (see the table below) that Sishen Pills is more than 75% effective in treating chronic colitis and irritable bowel syndrome (diarrhea type). Typical applicable scenarios include: diarrhea due to abdominal pain in the morning (latest night diarrhea), worsening diarrhea after eating raw and cold foods, and symptoms of kidney yang deficiency such as soreness and coldness in the waist and knees. It should be noted that it should be strictly distinguished from damp-heat diarrhea (anal burning, smelly feces), and this prescription is contraindicated in the latter.

Paragraph 4: Precautions for use
During the period of taking it, you need to avoid eating cold, greasy food, and you should stop using it when you have a cold or fever. The interval between combined use with antibiotics should be more than 2 hours to avoid affecting the efficacy of the medicine. Pregnant women and those with yin deficiency and excessive fire (shown as dry mouth, hot flashes and night sweats) should use with caution. It is recommended to take it on an empty stomach before breakfast and before going to bed to enhance the warming and tonic effect. Modern pharmacological research suggests that its antidiarrheal mechanism is related to regulating intestinal flora and reducing intestinal mucosal permeability.

Paragraph 5: Summary and extension
Sishen Pill is a classic prescription that has been proven for more than 400 years. Its value lies in the wisdom of formulating prescriptions to treat both the symptoms and the root causes. Compared with simple antidiarrheal drugs, it achieves long-term regulation by restoring the yang qi function of the spleen and kidneys. However, it needs to be emphasized that traditional Chinese medicine pays attention to syndrome differentiation and treatment, and it is recommended to use it under the guidance of a physician. For sub-health states such as "diarrhea caused by air-conditioning disease" and "diarrhea after staying up late" that are common among modern people, after excluding organic diseases, reasonable application under professional guidance can be considered.

Quote sources:
1. "Principles of Syndrome and Treatment" (Wang Kentang, Ming Dynasty)
2. "Pharmacopoeia of the People's Republic of China" 2020 Edition
3. Clinical data are quoted from "Chinese Journal of Integrated Traditional Chinese and Western Medicine" Issue 12, 2018
4. For the theory of compatibility, please refer to "Prescription Science" (People's Medical Publishing House)