Cefaclor Encyclopedia

First paragraph: content overview

Cefaclor is a second-generation oral cephalosporin antibiotic mainly used to treat infections of the respiratory tract, urinary tract, skin and soft tissues caused by sensitive bacteria. It is characterized by broad antibacterial spectrum, high bioavailability and good safety. This article will start fromPharmacological effects, indications, usage and dosage, adverse reactions and manufacturerExpand and focus on analyzing its clinical value and principles of rational drug use. Secondary content covers drug interactions and medication precautions for special populations.

Paragraph 2: Pharmacological effects and indications

Cefaclor exerts a bactericidal effect by inhibiting bacterial cell wall synthesis and is effective against Gram-positive bacteria (such as Streptococcus pneumoniae) and some Gram-negative bacteria (such as Escherichia coli).Main indicationsIncluding: acute otitis media, pharyngitis, tonsillitis, bronchitis and other respiratory infections, as well as simple urinary tract infections and skin infections. Clinical studies have shown that it has significant efficacy in treating common infections in children, and its gastrointestinal tolerance is better than some similar drugs (Source: "Chinese Journal of Antibiotics" 2021).

Paragraph 3: Usage, Dosage and Precautions

The conventional dose for adults is 250 mg every 8 hours, and for children, 20 mg/kg/day in divided doses. Note:Patients with renal insufficiency require dose adjustment, avoid combination with probenecid (may increase plasma concentration). Common adverse reactions include diarrhea, rash, and rare pseudomembranous colitis. Liver function should be monitored during medication, as long-term use may cause secondary infections (Source: US FDA drug instructions).

Paragraph 4: Manufacturer and product information

Many domestic pharmaceutical companies produce cefaclor, and common dosage forms include capsules, granules and dispersible tablets. The main manufacturers and products are as follows:

Different dosage forms are suitable for different groups of people. For example, granules are more suitable for children (Source: Official website of the State Food and Drug Administration).

Paragraph 5: Summary and suggestions for rational medication use

Cefaclor, as a classic oral antibiotic, plays an important role in the treatment of mild to moderate infections. When using it shouldStrictly follow medical instructions, to avoid abuse leading to drug resistance. Special groups (pregnant women, lactating women) need to evaluate the risk-benefit ratio. By choosing the appropriate dosage form and standardizing the course of treatment, the efficacy can be maximized and the risk of adverse reactions can be reduced.

Quote sources:

1. "Chinese Journal of Antibiotics" 2021 Volume 46 Issue 3
2. U.S. FDA Cefaclor Drug Insert (NDA 050405)
3. National Medical Products Administration Data Query System (NMPA)
4. Manufacturers disclose drug instructions (Suzhou Sinochem, Baiyunshan, etc.)