Vitamin K1: the natural guardian of blood coagulation and bone health

Vitamin K1 (phylloquinone) is an important member of the fat-soluble vitamin K family and is mainly involved in blood coagulation and bone metabolism. Its core features includePromote the synthesis of coagulation factors,Regulate calcium deposition, deficiency may lead to bleeding tendencies or osteoporosis. The natural sources are mainly green leafy vegetables (such as spinach, kale), and it is also used clinically to prevent neonatal hemorrhage. This article will systematically introduce its mechanism of action, applicable groups, supplementary suggestions and common products on the market.

1. Physiological functions and importance of vitamin K1

Vitamin K1 is activated byCoagulation factors Ⅱ, Ⅶ, Ⅸ, ⅩThe carboxylation process maintains normal coagulation function. Research shows that adults need to consume 90-120 μg daily, while newborns need additional supplements when their intestinal flora is not established. Furthermore, it assistsOsteocalcinSynthesis, promotes the directional deposition of calcium in bones instead of blood vessels, reducing the risk of arterial calcification. The National Institutes of Health (NIH) points out that there is a potential link between vitamin K1 deficiency and chronic diseases, such as cardiovascular disease.

2. Which groups of people need to focus on vitamin K1 intake?

The following groups of people are prone to deficiencies:People who take antibiotics for a long time(intestinal flora is suppressed),Hepatobiliary disease patients(Fat malabsorption),Pregnant women and newborns. The Chinese Nutrition Society recommends that lactating women require 120 μg daily, and premature infants require intramuscular injection of 0.5-1 mg after birth to prevent hemorrhage. The general population can supplement through diet. For example, 100g of cooked spinach contains about 145μg of vitamin K1.

3. Vitamin K1 supplementation methods and product selection

In addition to diet, commonly used clinicallyinjection(such as "Vitamin K1 Injection" produced by China Resources Shuanghe) andOral preparation. Please note when choosing: Injections need to be prescribed by a doctor. Oral products can refer to the following common brands:

4. Summary and safety tips

Vitamin K1 is a key nutrient for maintaining life activities, but excessive supplementation may interfere with the effect of anticoagulant drugs (such as warfarin). Healthy people should get it from their diet first, and people with special needs should use it under the guidance of a doctor. There is currently no evidence that it has extraordinary effects such as "anti-cancer" and "anti-aging", so commercial propaganda needs to be viewed rationally.

Quote sources:
1. "Reference Intake of Dietary Nutrients for Chinese Residents (2023 Edition)" by the Chinese Nutrition Society
2. National Institutes of Health (NIH) Special Report on Vitamin K
3. Product manuals of China Resources Shuanghe Pharmaceutical and Zhejiang Ruixin Pharmaceutical