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2026-03-10 05:49:22
Sini Powder: a classic prescription for soothing the liver, relieving stagnation, and reconciling qi and blood.
Sini Powder is one of the classic prescriptions of traditional Chinese medicine. It comes from "Treatise on Febrile Diseases". It is composed of four herbs: Bupleurum, peony, Citrus aurantium and licorice. It is mainly used to treat symptoms such as coldness in the limbs, swelling and pain in the chest and hypochondrium caused by liver qi stagnation and disharmony of qi and blood. This article will focus on four aspects: prescription composition, efficacy principle, applicable symptoms and modern applications to help readers fully understand this traditional prescription. In terms of primary and secondary structure, basic information is introduced first, then its mechanism of action is analyzed in depth, and finally the practical application value is discussed.
Prescription composition and compatibility characteristics

Sini Powder uses Bupleurum as the monarch medicine to soothe the liver and relieve depression; peony as a ministerial medicine to soften the liver and nourish blood; Citrus aurantium as an adjuvant medicine to break qi stagnation; and licorice as an envoy medicine to reconcile various medicines. The compatibility of the four medicines embodies the core idea of traditional Chinese medicine of "soothing the liver, relieving stagnation, and reconciling qi and blood." Among them, Bupleurum and Peony are used to strengthen and balance liver qi; while Citrus aurantium and Licorice are used to break and tonify, both attacking and tonifying. This exquisite combination makes it a classic prescription for regulating poor Qi.
Efficacy principle and applicable symptoms
Sini Powder relieves liver stagnation and unblocks qi, improving qi and blood blockage caused by emotional depression or invasion of external evils. Typical symptoms include: lukewarm limbs ("Four Ni"), distension and tightness in the chest and hypochondrium, epigastric and abdominal pain, depression, etc. Modern research shows that this prescription can regulate autonomic nervous function, relieve smooth muscle spasm, and has auxiliary effects on functional indigestion, chronic gastritis and other diseases.
Modern applications and considerations
In contemporary clinical practice, Sini Powder is often used for digestive system diseases (such as irritable bowel syndrome), gynecological diseases (such as irregular menstruation) and emotional-related diseases. Syndrome differentiation and treatment are required when using: use with caution in those with yang deficiency and excessive cold, and pregnant women should follow the doctor's advice to adjust the compatibility. Its derivative formulas (such as Bupleurum Shugan Powder) further expand the scope of application and reflect the flexibility of traditional Chinese medicine in "treating different diseases with the same treatment".
Summary and value inheritance
Sini Powder, as a precious legacy left by Zhang Zhongjing, demonstrates the wisdom of traditional Chinese medicine in "regulating qi and harmonizing yin and yang" in a concise formula. From ancient times to the present, it has not only been a special prescription for treating the symptoms of the "Four Niss", but has also become a basic prescription for soothing the liver and relieving stagnation. A correct understanding of its indications and contraindications can enable this thousand-year-old prescription to continue to exert its unique value in modern medical treatment.
| Composition of drugs | Dosage (classic ratio) |
| Bupleurum | 6-12g |
| Peony | 6-12g |
| Citrus aurantium | 6-10g |
| Licorice | 3-6g |
Quote sources:1. "Treatise on Febrile Diseases" by Zhang Zhongjing 2. "Pharmacopoeia of the People's Republic of China" (2020 edition) 3. For modern research data, refer to "Traditional Chinese Medicine Prescriptions" (People's Medical Publishing House)
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