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Wupisan
2026-04-10 18:17:24
Wupisan: Analysis of traditional prescription for diuresis and swelling
Wupisan is one of the classic prescriptions of traditional Chinese medicine, mainly used to treat edema, dysuria and other conditions. This article will start from four aspects: its composition, efficacy, clinical application and modern research, focusing on analyzing its compatibility principle and practical application value to help readers fully understand the primary and secondary content structure of this prescription.
1. Composition and compatibility principles of Wupisan

Wupisan is composed of five herbs: mulberry white bark, tangerine peel, poria bark, big belly peel and ginger peel. They all take the meaning of "treating the skin with the skin" and are aimed at edema syndrome of stagnant muscle surface due to water-dampness. Mulberry bark purges the lungs and promotes diuresis, Poria bark strengthens the spleen and exudes dampness, Tangerine peel regulates qi and resolves dampness, Big Belly bark promotes qi and expands the middle, and ginger peel disperses water and soothes the spleen. The five medicines work together to promote qi, strengthen the spleen, diuresis and reduce swelling. This recipe has exquisite compatibility and embodies the treatment concept of "holistic adjustment" of traditional Chinese medicine.
2. Clinical application and indications
Wupisan is suitable forEdema due to spleen deficiency and excessive dampness, common in mild to moderate edema associated with chronic nephritis, heart failure and other diseases. Clinical manifestations include edema of eyelids or lower limbs, lack of urination, white and greasy tongue coating, etc. Modern research shows that its active ingredients can relieve symptoms through diuresis, anti-inflammatory and other pathways (see table below). However, it should be noted that patients with severe renal insufficiency need to be combined with other treatments.
| Ingredients | Main function | Modern research support |
|---|---|---|
| Mulberry white bark | diuretic, anti-inflammatory | Contains morrin to promote sodium excretion |
| Poria bark | Regulate water and salt metabolism | Polysaccharides enhance immunity |
3. Precautions and taboos for use
Wupisan has a mild nature and flavor, butPeople with yin deficiency and fluid deficiency should use with caution, so as not to aggravate symptoms such as dry mouth and constipation. Pregnant women should use it under the guidance of a physician. The traditional decoction method is 1 dose per day, divided into 2 times and taken warmly, and the effect is observed for 3-5 days. If edema persists or worsens, you should seek medical advice promptly to investigate the cause and avoid delaying treatment.
4. Summary and extension
As a basic prescription for diuresis in traditional Chinese medicine, Wupisan is both safe and practical, and is especially suitable for treating mild edema. Its formulation ideas also inspire the research and development of modern traditional Chinese medicine, such as the application of the theory of "treating skin with skin" in the treatment of skin diseases. When using it, it needs to be treated based on syndrome differentiation and combined with lifestyle adjustments (such as low-salt diet) to achieve the best results.
Quote sources:
1. "Taiping Huimin Hejiju Prescription" (Official Medical Code of the Song Dynasty) 2. Relevant discussion on the edema chapter in Zhang Zhongjing's "Synopsis of the Golden Chamber" 3. Modern pharmacological data refer to "Chinese Materia Medica" (compiled by the State Administration of Traditional Chinese Medicine)
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